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Author: Naito, H.; Masui, M.; Imamoto, T.; Ishiki, S.; Komiya, A.; Ito,
H.
Year: 1999
Title: [Intra-arterial chemotherapy for invasive bladder cancer]
Journal: Gan To Kagaku Ryoho
Volume: 26
Issue: 12
Pages: 1948-50
Label: 20024223
Keywords: Adult
Aged
Aged, 80 and over
Antineoplastic Agents, Combined/*therapeutic use
Bladder Neoplasms/*drug therapy/mortality
Carcinoma, Transitional Cell/*drug therapy/mortality
Cisplatin/administration & dosage
Doxorubicin/analogs & derivatives/administration & dosage
English Abstract
Female
Follow-Up Studies
Human
Infusions, Intra-Arterial
Male
Middle Age
Survival Rate
Treatment Outcome
Abstract: Between July 1993 and May 1999, 36 patients with invasive bladder
cancer were treated with intra-arterial chemotherapy using cisplatin
and pirarubicin, and their treatment outcome was evaluated. Clinical
CR was obtained in 18 patients, PR in 13, and NC in 5, for an
overall response rate of 86%. The median follow-up for evaluating
patients was 24 months (2-70 months). The bladder was preserved
in 13 of 18 patients showing CR and in 4 of 13 patients showing
PR. The 5-year cause- specific survival rate for the 36 patients
was 56%. The grade factor did not effect the survival rate significantly.
Compared with stage T2, stage T3 yielded a significantly poor
prognosis, especially with grade 3. Intra-arterial chemotherapy
was confirmed useful as a regional treatment, but not sufficient
as a systemic treatment. Thus the selection of patients for this
therapy was considered to require exact staging and assessment
of the effectiveness.