go to Japanese home page.....
15
Author: Uzawa, K.; Suzuki, H.; Komiya, A.; Nakanishi, H.; Ogawara, K.;
Tanzawa, H.; Sato, K.
Year: 1996
Title: Evidence for two distinct tumor-suppressor gene loci on the
long arm of chromosome 11 in human oral cancer
Journal: Int J Cancer
Volume: 67
Issue: 4
Pages: 510-4
Label: 96323312
Keywords: Carcinoma, Squamous Cell/*genetics/pathology
*Chromosome Deletion
Chromosome Mapping
*Chromosomes, Human, Pair 11
DNA, Satellite
Gene Deletion
*Genes, Suppressor, Tumor
Genetic Markers
Human
Lymphatic Metastasis
Mouth Neoplasms/*genetics/pathology
Neoplasm Staging
Polymerase Chain Reaction
Support, Non-U.S. Gov't
Abstract: Loss of heterozygosity (LOH) on human chromosome 11 has been
reported in a variety of human cancers. To search for the existence
of tumor- suppressor gene(s) associated with oral squamous cell
carcinoma (SCC) on chromosome 11, we have performed high-resolution
deletion mapping in 31 patients with oral SCC using 22 microsatellite
markers for this chromosomal region. LOH was observed in 14 of
25 cases (56.0%) that were informative with at least one locus.
Most allelic deletions detected in our study were specific to
the long arm of the chromosome. Furthermore, the data presented
here show 2 distinct, commonly deleted regions. The first region,
with frequent LOH, was restricted between markers DIIS939 and
DIIS924 separated by 3 centimorgans (cM) on chromosome 11q23.
The second region of common deletion was identified between markers
DIIS912 and DIIS910, separated by 7 cM at 11q25. Our results suggest
that at least 2 tumor-suppressor genes involved in the development
of oral SCC are present on the long arm of chromosome 11.