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Functions
- Tryptophan is a precursor of niacin(requires vitamin B2)
- Needed for more than 200 enzymes involved in metabolism of carbohydrate,
fatty acids, and amino acids.
- Proper blood circulation
- Lower cholesterol
- Nervous system function
- Synthesis of certain hormones
- Active coenzymes forms are NAD+ and NADP+
- Useful in the treatment of type llb hyperlipoproteinemia, where
both VLDL and LDL are elevated
- Retained in tissues by being converted mostly to NADH but also
NADOH
- NADH and NADPH are needed for more than 200 enzymes involved
in metabolism of carbohydrate, fatty acids, and amino acids.
- NADH and NADPH are the most central electron carriers of cells
- De novo synthesis of NADH and NADPH occurs from a metabolite
of tryptophan
- De novo synthesis of NADH and NADPH involves FAD- (riboflavin
) and pyridoxal phosphatet(vitamin B6)-dependent stepes
- 60 mg tryptophan is required to produce 1mg niacin
- Both NADH and NADPH can be produced from NA and Nam obtained
from diet
Recommended Dietary Allowance(Female in 20's, healty, non-pregnant)
14 mg/day
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